Hydroxychloroquine for Early Systemic Sclerosis

We are studying whether adding hydroxychloroquine to standard treatments helps improve symptoms in people with early systemic sclerosis. The trial will assess its safety and effectiveness compared to a placebo.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Plaquenil
Plaquenil is a medicine used to treat malaria and certain autoimmune conditions like lupus and rheumatoid arthritis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Hydroxychloroquine Sulfate
Hydroxychloroquine sulfate is a substance used to prevent or treat malaria and to help control autoimmune conditions such as lupus and rheumatoid arthritis.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Autokila
Dolquine
Duplaxil

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dipartimento di Medicina Interna
La Massimina-Casal Lumbroso, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I
Dipartiemnto di medicina traslazionale e nutrizione clinica
Rome, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I
Scienze cliniche internistiche anestesiologiche e cardiovascolari
Rome, Italy
Sponsor: Azienda Ospedaliero-Universitaria Policlinico Umberto I
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.