Hypertension in Chronic Kidney Disease: Diuretic Treatment Study

We are investigating if a new diuretic-based treatment helps people with moderate to severe chronic kidney disease and uncontrolled hypertension. The goal is to see if it can reduce serious health issues like kidney failure and heart problems.

>2 years 6-10 visits Confirmation phase (III)No Placebo Standard Medicines OralCardiologyNephrology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Furosemide

Furosemide is a medicine that helps the body get rid of extra water and salt to reduce swelling and lower blood pressure.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Amiloride Hydrochloride

Amiloride hydrochloride is a substance that reduces fluid buildup and helps lower high blood pressure while conserving potassium.

Furosemide

Furosemide is a substance that helps the body remove excess fluid and salt, reducing swelling and lowering blood pressure.

Hydrochlorothiazide

Hydrochlorothiazide is a substance that helps the body remove excess fluid to lower high blood pressure and reduce swelling.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Co-Amilofruse

Co-Amilofruse Wockhardt Uk

Demefur

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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CENTRE HOSPITALIER DE VALENCIENNES

Nephrology

Anzin, France

Assistance Publique Hopitaux De Paris

Nephrology

Bagnolet, France

CHU Gabriel-Montpied

Nephrology

Beaumont, France

Sponsor: Centre Hospitalier Regional Universitaire De Tours

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.