Hypophosphatasia
Hypophosphatasia (HPP) is a rare genetic disorder characterized by defective bone mineralization, leading to weak bones and a variety of symptoms including bone pain, fractures, and dental issues.
Hypophosphatasia: ALXN1850 Treatment Study
We are studying a new treatment called ALXN1850 for adolescents and adults with hypophosphatasia who haven't been treated before. The goal is to see if it improves their daily functioning and quality of life compared to a placebo.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 12 years old?
- Do you have a diagnosis of hypophosphatasia (HPP)?
- Are you currently pregnant, planning to become pregnant, or breastfeeding?
- Have you received any bisphosphonate treatment (like Fosamax or Boniva) in the last 6 months?
- Have you had any new fractures in the last 12 weeks?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Alxn1850
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Hanusch Krankenhaus Der Wiener Gebietskrankenkasse
1. Medical Department
Vienna, Austria
UZ Leuven
Metabolic Center
Heverlee, Belgium
Association Hospitaliere De Bruxelles Hopital Universitaire Des Enfants Reine Fabiola
Nutrition and Metabolism Clinic
Jette, Belgium
Sponsor: Alexion Pharmaceuticals Inc.
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.