IDH1/IDH2-Mutant Glioma: Vorasidenib with Temozolomide

We are studying the safety and effectiveness of a new drug, vorasidenib, combined with temozolomide for patients with IDH1- or IDH2-mutant gliomas. This research aims to see if this combination can improve treatment outcomes.

>2 years Safety phase (I)Efficacy phase (II)Post-Trial Drug Access No Placebo Cost Reimbursement Partially Remote Investigational Medicines OralOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Temozolomide Accord

Temozolomide Accord is a chemotherapy medicine used to treat certain brain tumors.

Temozolomide Ratiopharm

Temozolomide Ratiopharm is a cancer medicine used to treat certain brain tumors, including glioblastoma.

Temozolomide Sun

Temozolomide Sun is a cancer medicine used to treat certain types of brain tumors.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Temozolomide

Temozolomide is a substance used in chemotherapy to treat certain types of brain tumors by slowing cancer cell growth.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

S95032

Vorasidenib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Advecit

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Vienna

Division of Oncology, Department of Medicine I

Vienna, Austria

Hospices Civils De Lyon

Service de neuro-oncologie

Bron, France

Oncopole Claudius Regaud

Oncologie Médicale

Portet-sur-Garonne, France

Sponsor: Institut De Recherches Internationales Servier IRIS

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.