Oral Disorders
Oral disorders refer to a range of conditions that affect the mouth, including issues with teeth, gums, and soft tissues. These can lead to symptoms such as pain, swelling, and difficulty eating or speaking.
Immunotherapy for High-Risk Oral Disorders: APHRODITE Trial
We are testing a new immunotherapy to see if it can prevent high-risk oral disorders from turning into cancer. The study will also look at the treatment's safety and its effects on patients' quality of life.
>2 yearsEfficacy phase (II)No PlaceboPartially RemoteInvestigational MedicinesInjectionOncologyOtolaryngology
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you over 18 years old?
- Do you have a diagnosis of high-risk oral potentially malignant disorder (OPMD) like leukoplakia or erythroplakia?
- Have you had any immunotherapy treatments in the past?
- Do you have any significant heart problems, like heart failure or uncontrolled high blood pressure?
- Have you had oral cavity squamous cell carcinoma in the past 2 years?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Mitazalimab
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Azienda Socio Sanitaria Territoriale Santi Paolo E Carlo
UO di Odontoiatria e Stomatologia II
Assago, Italy
Istituto Europeo Di Oncologia S.r.l.
Otorinolaringoiatria e Chirurgia Cervico Facciale
Opera, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
MEDICINA ORALE CON ODONTOIATRIA PER PAZIENTI FRAGILI
Palermo, Italy
Sponsor: Humanitas Mirasole S.p.A.
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.