Fever of Unknown Origin
Fever of unknown origin (FUO) is a condition where a person has a fever that lasts for more than three weeks without an identified cause, often requiring extensive medical investigation.
Inflammatory Disorders: New Imaging Tracer 18F-AlF-FAPI-74
We are studying a new imaging tracer to see if it can better diagnose inflammatory disorders compared to the standard tracer. This trial includes patients with fever of unknown origin, IgG4-related disease, and axial spondyloarthritis.
>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesInjectionInternal MedicineOrthopedics and TraumatologyRheumatology
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
IgG4-Related Disease
IgG4-related disease is an autoimmune condition characterized by elevated levels of IgG4 antibodies, leading to inflammation and damage in various organs, often presenting with swelling and pain.
Axial Spondyloarthritis
Axial spondyloarthritis (AxSpA) is a type of inflammatory arthritis that primarily affects the spine and pelvis, causing pain and stiffness, particularly in the lower back.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you over 18 years old?
- Are you a woman who is pregnant, breastfeeding, or planning to become pregnant?
- Have you had a PET/CT scan or do you plan to have one in the next 4 weeks?
- Are you currently taking treatment for IgG4-related disease?
- Are you currently taking biological DMARDs for axial spondyloarthritis?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Alfapi-74
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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UZ Leuven
Nuclear Medicine
Heverlee, Belgium
Sponsor: UZ Leuven
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.