Irritable Bowel Syndrome: Ebastine vs. Mebeverine

We are comparing the effectiveness of ebastine and mebeverine for treating irritable bowel syndrome. The study also looks at how these treatments impact quality of life for patients.

3-6 months ≤5 visits Confirmation phase (III)Standard Medicines OralGastroenterologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Duspatalin

Duspatalin is a medicine that relaxes bowel muscle spasms to relieve abdominal pain and discomfort, commonly used for irritable bowel syndrome.

Duspatalin Retard

Duspatalin Retard is a slow-release medicine used to relieve abdominal pain and cramps from irritable bowel symptoms and other gut spasms.

Ebastine Eg

Ebastine EG is a medicine that relieves allergy symptoms such as sneezing, runny nose, and itchy or swollen skin.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ebastine

Ebastine is an antihistamine substance that relieves allergy symptoms like sneezing, runny nose, and itching.

Mebeverine Hydrochloride

Mebeverine hydrochloride is a substance that relaxes intestinal muscles to relieve abdominal cramps and spasms, often used for irritable bowel syndrome.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aurobeverine Mr

Auroverin Mr

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Gasthuiszusters Antwerpen

Gastro enterology

Antwerpen, Belgium

Sint-Lucas General Hospital

Gastro enterology

Assebroek, Belgium

UZ Leuven

Gastro enterology

Heverlee, Belgium

Sponsor: UZ Leuven

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.