Ischemic Stroke: Thrombolytic Therapy with rtPA

We are studying a new treatment for patients with acute ischemic stroke who are on blood thinners. The goal is to see if this therapy improves recovery compared to a placebo after reversing the blood thinner's effects.

3-6 months ≤5 visits Efficacy phase (II)Partially Remote Standard Medicines InjectionInternal MedicineNeurology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Actilyse 10

Actilyse 10 is a medicine used to dissolve dangerous blood clots in heart attacks, some types of stroke, and serious lung clots.

Actilyse 20

Actilyse 20 is a medicine used to dissolve blood clots during heart attacks, certain strokes, and serious lung clots.

Actilyse 50

Actilyse 50 is a medicine used in emergencies to dissolve blood clots that cause strokes, heart attacks, or serious lung clots.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Alteplase

Alteplase is a substance that dissolves blood clots to restore blood flow in emergencies like stroke, heart attack, or pulmonary embolism.

Andexanet Alfa

Andexanet alfa is a substance used to quickly reverse the effects of certain blood thinners during serious bleeding.

Sodium Chloride

Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Actilyse

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie

Oddział Kliniczny Neurologii

Grzegórzki, Poland

Gornoslaskie Centrum Medyczne Im Prof. Leszka Gieca Sląskiego Uniwersytetu Medycznego W Katowicach

Klinika Neurologii

Katowice, Poland

Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M.Kopernika W Lodzi

Regionalne Centrum Profilaktyki i Leczenia Udarów Mózgu

Łódź, Poland

Sponsor: Medical University Of Gdansk

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.