Isolated MMA: Long-Term Study of mRNA-3705

We are evaluating the long-term safety and effects of mRNA-3705 in individuals with Isolated MMA who have participated in earlier studies. This research aims to understand how the treatment impacts health and daily activities over time.

Safety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboPartially RemoteInvestigational MedicinesOralInjectionInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ibuprofen
Ibuprofen is a medicine used to relieve pain, reduce inflammation, and lower fever from headaches, muscle aches, and minor injuries.
Paracetamol
Paracetamol relieves pain and reduces fever for conditions like headaches, muscle aches, and colds.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cetirizine Dihydrochloride
Cetirizine Dihydrochloride is an antihistamine that relieves allergic symptoms like sneezing, runny nose, itchy eyes, and hives.
Dexamethasone
Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.
Dexamethasone Phosphate
Dexamethasone phosphate is a corticosteroid substance that reduces inflammation and suppresses immune system activity.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mrna-3705
Modified Mrna Encoding Human Methylmalonyl-Coenzyme A Mutase

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

200 Mg + 500 Mg
3 Months Ibuprofen Strawberry Flavour
3 Months Plus Strawberry Flavour

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire De Toulouse
Blagnac, France
Centre Hospitalier Regional De Marseille
Marseille, France
Assistance Publique Hopitaux De Paris
Service de Maladies métaboliques pédiatriques
Montrouge, France
Sponsor: Moderna Therapeutics Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.