Kidney Cancer: Savolitinib Plus Durvalumab Study

We are exploring whether a new combination treatment can help patients with advanced papillary renal cell carcinoma live longer and feel better compared to standard therapies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Flixabi
Flixabi is a medicine used to reduce inflammation in autoimmune conditions like rheumatoid arthritis, Crohn's disease, and psoriasis.
Myfenax
Myfenax is a medicine used to prevent organ transplant rejection by suppressing the immune system.
Sutent
Sutent is a cancer medicine used to treat certain kidney, stomach, and pancreatic tumors.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Durvalumab
Durvalumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein tumors use to hide.
Infliximab
Infliximab is a substance that reduces inflammation by blocking a protein called TNF and is used for autoimmune conditions like rheumatoid arthritis and Crohn's.
Mycophenolate Mofetil
Mycophenolate mofetil is a substance that suppresses the immune system to prevent organ transplant rejection and treat autoimmune conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Savolitinib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cellcept
Egotux
Inflectra

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fakultni Nemocnice Brno
Interní hematologická a onkologická klinika
Brno, Czechia
Fakultni Nemocnice Bulovka
Institut radiační onkologie
Dolní Chabry, Czechia
Fakultni Nemocnice Hradec Kralove
Klinika onkologie a radioterapie
Hradec Králové, Czechia

Sponsor: AstraZeneca AB
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.