Knee Osteoarthritis: Intra-Articular Clodronate Study

We are investigating whether different doses of clodronate can help reduce knee pain and improve function in people with painful knee osteoarthritis. The study will also monitor safety and tolerability of the treatment.

>2 years 6-10 visits Efficacy phase (II)Confirmation phase (III)Post-Trial Drug Access Standard MedicinesOrthopedics and TraumatologyRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Clodronate Disodium

Clodronate disodium is a substance that prevents bone loss, lowers high blood calcium, and can reduce bone pain.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...

Ospedale Santa Maria Regina degli Angeli di Adria - ULSS 5 Polesana

Ortopedia e Traumatologia

Adria, Italy

Azienda Ospedaliero-Universitaria Ss.Antonio E Biagio E C.Arrigo Alessandria

Centro Riabilitativo Polifunzionale Teresio Borsalino

Alessandria, Italy

Azienda Sanitaria Locale Della Provincia Di Barletta Andria Trani

Ortopedia Ospedale Lorenzo Bonomo

Andria, Italy

Sponsor: Spa Societa Prodotti Antibiotici S.p.A.

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.