Knee Surgery Pain Relief: Nefopam Study

We are investigating whether an oral medication called nefopam can reduce morphine use after total knee replacement surgery. This study aims to improve pain management for adults recovering from this procedure.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Morphine (Chlorhydrate) Aguettant
A strong prescription medicine used to relieve severe pain, often after surgery or for serious chronic pain.
Morphine (Chlorhydrate) Lavoisier
Morphine (Chlorhydrate) Lavoisier is a painkiller medicine used to relieve severe or persistent pain.
Nefopam Panpharma
Nefopam Panpharma is a medicine used to relieve moderate to severe pain.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Morphine Hydrochloride
Morphine hydrochloride is a substance that relieves severe pain by decreasing the body's perception of pain.
Morphine Sulfate
Morphine sulfate is a substance used to relieve severe pain, especially after injury or during surgery.
Nefopam
Nefopam is a substance that relieves moderate to severe pain by acting on the central nervous system.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Schweppes

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acupan
Anefaltic
Azuzote

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Hospital La Croix Rousse Hcl
Anesthésie Réanimation
Caluire-et-Cuire, France
Sponsor: Hospices Civils De Lyon
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.