Leukemia and Lymphoma: Ruxolitinib and Venetoclax Study

We are studying the safety and effectiveness of ruxolitinib and venetoclax in children with relapsed or refractory leukemia or lymphoma that have specific genetic mutations. This research aims to find better treatment options for these young patients.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Jakavi
Jakavi is a medicine used to treat certain serious blood disorders that affect bone marrow and blood cell production.
Venclyxto
Venclyxto is a medicine used to treat certain types of blood cancer, including some forms of leukemia and lymphoma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ruxolitinib
Ruxolitinib is a substance that blocks cell signals to reduce abnormal blood cell growth and inflammation in certain bone marrow disorders.
Venetoclax
Venetoclax is a substance used to treat certain blood cancers by helping cancer cells die.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Opzelura

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
St. Anna Kinderspital GmbH
pediatric oncology and hematology
Vienna, Austria
Universitair Ziekenhuis Gent
Paediatric Haemato-oncology
Ledeberg, Belgium
Rigshospitalet
Department of Paediatrics and Adolescent Medicine
Copenhagen, Denmark

Sponsor: Princess Maxima Center For Pediatric Oncology
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.