Leukemia Treatment: Ponatinib vs. Imatinib

We are studying whether ponatinib combined with chemotherapy is as effective as imatinib for adults with Philadelphia-Chromosome positive acute lymphoblastic leukemia. The trial also evaluates treatment outcomes for patients who respond differently.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Blincyto
Blincyto is a cancer medicine used to treat certain types of acute lymphoblastic leukemia by helping the immune system target leukemia cells.
Iclusig
Iclusig is a cancer medicine used to treat certain types of leukemia, especially when other treatments have not worked.
Imatinib
Imatinib is a cancer medicine used to treat certain blood cancers and tumor types by blocking cancer cell growth.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Blinatumomab
Blinatumomab is a substance that directs the immune system to attack certain leukemia cells, used for treating some types of acute lymphoblastic leukemia.
Imatinib
Imatinib is a substance that blocks signals cancer cells need to grow, used for chronic myeloid leukemia and some gastrointestinal tumors.
Ponatinib
Ponatinib is a substance that blocks cancer cell growth signals and is used to treat certain types of leukemia, including resistant chronic myeloid leukemia.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bimatix
Glipox
Glivec

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Klinikum Bayreuth GmbH
Hämatologie und internistische Onkologie
Bayreuth, Germany
Charite Universitaetsmedizin Berlin KöR
Med. Kl. m. S. Hämatologie, Onkologie und Tumorimmunologie
Berlin, Germany
Charite Universitaetsmedizin Berlin KöR
Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie
Berlin, Germany

Sponsor: Goethe University Frankfurt
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.