Leukemia: Venetoclax with Stem Cell Transplant

We are evaluating the safety and effectiveness of Venetoclax combined with standard treatment for patients with high-risk MDS, CMML, or sAML undergoing stem cell transplantation. This study aims to improve outcomes and reduce complications during treatment.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Allopurinol
Allopurinol is a medicine that lowers uric acid to prevent and treat gout and certain kidney stones.
Cytarabine
Febuxostat
Febuxostat is a medicine used to lower uric acid levels and help prevent gout attacks.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Allopurinol
Allopurinol is a substance that lowers uric acid levels to prevent gout attacks and related complications.
Amsacrine
Amsacrine is a substance used to treat certain cancers, especially leukemia, by interfering with cancer cell DNA replication.
Anti-T Lymphocyte Immunoglobulin For Human Use
Anti-T lymphocyte immunoglobulin is a preparation of antibodies that reduces activity of immune T cells to prevent or treat organ transplant rejection.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abuxar
Accofil
Acepurin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitaetsklinikum Duesseldorf AöR
Klinik für Hämatologie, Onkologie und Klinische Immunologie
Düsseldorf, Germany
Universitaetsklinikum Frankfurt AöR
Medizinische Klinik II
Frankfurt am Main, Germany
Universitaetsklinikum Jena KöR
Klinik für Innere Medizin II
Jena, Germany

Sponsor: Heinrich-Heine-Universitaet Duesseldorf
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.