Limited-Stage Small-Cell Lung Cancer: Tarlatamab Study

We are studying whether tarlatamab can improve survival and prevent disease progression in patients with limited-stage small-cell lung cancer after chemoradiation therapy. Participants will receive either tarlatamab or a placebo to compare their effects.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Argipressin Aop
Argipressin Aop is a medicine used to raise blood pressure and reduce excessive urine output in certain medical conditions.
Paracetamol
Paracetamol relieves pain and reduces fever for conditions like headaches, muscle aches, and colds.
Prednisolone Eg
Prednisolone Eg is a steroid medicine used to reduce swelling and treat allergies, asthma attacks, and certain immune system conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Argipressin
Argipressin is a hormone-like substance that raises blood pressure by narrowing blood vessels and reduces severe bleeding.
Betamethasone Sodium Phosphate
Betamethasone sodium phosphate is a corticosteroid substance that reduces inflammation and suppresses immune reactions in allergic, inflammatory, and skin conditions.
Buclizine Hydrochloride
Buclizine hydrochloride is an antihistamine substance used to prevent nausea, vomiting, and motion sickness.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Tarlatamab
Electrolytes

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

4-In-One Flu Relief
6 Years Plus Paracetamol Boots
Abacat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz
Department of Internal Medicine
Graz, Austria
Medical University Of Vienna
Department of Medicine I
Vienna, Austria
Universitair Ziekenhuis Gent
Longziekten
Ledeberg, Belgium

Sponsor: Amgen Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.