Linvoseltamab for Relapsed or Refractory AL Amyloidosis

We are studying whether linvoseltamab is safe and effective for adults with relapsed or refractory systemic light chain amyloidosis. The trial will help us understand its impact on blood response and overall health.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Paracetamol 500 Mg Tablets
Paracetamol 500 mg tablets relieve mild to moderate pain and reduce fever.
Roactemra
Roactemra is a medicine used to reduce inflammation and treat autoimmune conditions such as rheumatoid arthritis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dexamethasone
Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.
Dexamethasone Phosphate
Dexamethasone phosphate is a corticosteroid substance that reduces inflammation and suppresses immune system activity.
Dexamethasone Sodium Phosphate
Dexamethasone sodium phosphate is a corticosteroid substance that reduces inflammation and suppresses the immune response.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Diphenhydramine
Regn88
Dexamethasone

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Avtozma
Clear Dissolving Pain Relief
Decongestant With Pain Relief

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Alexandra Hospital
Department of Clinical Therapeutics of National and Kapodistrian University of Athens
Athens, Greece
Hospital Clinic De Barcelona
Hematology
El Altet, Spain
Hospital Universitario De Cabuenes
Hematology
Gijón, Spain

Sponsor: Regeneron Pharmaceuticals Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.