Locally Advanced Rectal Cancer
Locally advanced rectal cancer is a type of cancer that has spread from the rectum to nearby tissues or lymph nodes but has not metastasized to distant organs. It often requires aggressive treatment.
Locally Advanced Rectal Cancer: FOLFOX Before Surgery
We are comparing the effects of chemotherapy before surgery to risk-adapted chemotherapy after surgery for patients with locally advanced rectal cancer. Our goal is to see which approach may lead to better disease-free survival and fewer complications.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 18 years old?
- Do you have rectal cancer that is localized (not spread to other parts of the body)?
- Are you currently pregnant or breastfeeding?
- Have you had major surgery in the last 4 weeks?
- Do you have serious heart problems, like a heart attack or unstable angina, in the last 6 months?
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
Capecel
Capecitabin Al
Capecitabin Amarox
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Klinikum St Marien Amberg
Studienzentrum
Amberg, Germany
Haematologie-Onkologie im Zentrum MVZ GmbH
Fachärzte für Innere Medizin, Hämatologie und Onkologie
Augsburg, Germany
Charite Universitaetsmedizin Berlin KöR
Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie am CVK
Berlin, Germany
Sponsor: Heidelberg University
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.