Locally Recurrent Rectal Cancer: Induction Chemotherapy Study

We are comparing the effects of induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone for patients with locally recurrent rectal cancer. This study aims to see which approach leads to better surgical outcomes and survival rates.

Confirmation phase (III)No Placebo Partially Remote Investigational Medicines Oral InjectionGastroenterologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Fluorouracil Teva

Fluorouracil Teva is a cancer medicine used to treat several types of cancer by slowing or stopping cancer growth.

Xeloda

Xeloda is an oral chemotherapy medicine used to treat certain cancers, including colorectal and breast cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate

Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.

Capecitabine

Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.

Fluorouracil

Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Irinotecan

Teysuno

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

5-Fluorouracil

5-Fluorouracil Ebewe

5-Fluorouracil Sandoz

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitair Ziekenhuis Gent

Surgery

Ledeberg, Belgium

Jeroen Bosch Ziekenhuis

Medical Oncology

's-Hertogenbosch, Netherlands

Academic Medical Center At The University Of Amsterdam

Surgery

Abcoude, Netherlands

Sponsor: Catharina Ziekenhuis Stichting

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.