Long-term Safety of Genetically Modified T Cell Therapy

We are following up with patients who received genetically modified T cells to assess their long-term safety and survival. This study aims to understand how well the treatment works and any potential risks involved.

>2 years>20 visitsEfficacy phase (II)No PlaceboPartially RemoteStandard MedicinesInjectionHematologyOncologyRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Avtozma
Mabthera
Mabthera is a medicine used to treat certain blood cancers and some autoimmune diseases by targeting problematic immune cells.
T4

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Levothyroxine Sodium
Levothyroxine sodium is a substance used to replace low thyroid hormones.
Rituximab
Rituximab is a substance that targets and reduces B cells, a type of white blood cell, to treat some blood cancers and autoimmune conditions.
Tisagenlecleucel
Tisagenlecleucel is a cell-based therapy that uses a patient's own modified immune cells to target and kill certain B-cell cancers.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Accu-Thyrox
Althyxin
Blitzima

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Hospital Universitari Vall D Hebron
Paediatric Haemato-Oncology
Barcelona, Spain
Hospital Infantil Universitario Nino Jesus
Paediatric Haemato-Oncology
Madrid, Spain
Hospital Universitario Y Politecnico La Fe
Hematology
Sedaví, Spain
Sponsor: Autolus Limited
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.