Lupus Nephritis: Obinutuzumab for Adolescents

We are studying the effects of obinutuzumab in adolescents with active lupus nephritis to see if it is more effective than a placebo. The trial also includes younger children to evaluate safety and how the drug works in them.

>2 years Efficacy phase (II)Post-Trial Drug Access Partially Remote Standard Medicines Oral InjectionNephrologyPediatricsRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cellcept

Cellcept is a medicine that helps prevent a transplanted organ from being rejected by the immune system.

Gazyvaro

Gazyvaro is a cancer medicine used to treat certain blood cancers, including some types of lymphoma and chronic lymphocytic leukemia.

Myfenax

Myfenax is a medicine used to prevent organ transplant rejection by suppressing the immune system.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Mycophenolate Mofetil

Mycophenolate mofetil is a substance that suppresses the immune system to prevent organ transplant rejection and treat autoimmune conditions.

Obinutuzumab

Obinutuzumab is a lab-made antibody that targets and helps eliminate B cells to treat certain blood cancers like chronic lymphocytic and follicular lymphoma.

Placebo

Placebo is an inactive substance given to mimic a treatment so researchers can measure effects caused by patients' expectations.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Micofenolat Mofetil Sandoz

Micofenolat Mofetil Stada

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire De Toulouse

Pediatrie - Nephrologie, Medecine interne et Hypertension

Blagnac, France

Assistance Publique Hopitaux De Paris

Pediatrie

Croulebarbe, France

Assistance Publique Hopitaux De Paris

Nephrologie pediatrique

Le Pré-Saint-Gervais, France

Sponsor: F. Hoffmann-La Roche AG

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.