Major Depression: Samyr Injection Study

We are testing whether Samyr, an injectable treatment, can improve symptoms in people with major depression who are not responding well to their current antidepressants. This study compares Samyr to a placebo to assess its effectiveness and safety.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Samyr
Samyr is a medicine used to help treat depression and relieve joint pain.
Sodio Cloruro Fresenius Kabi Italia
Sodio Cloruro Fresenius Kabi Italia is a sterile saline solution used to replace body fluids and salts and to rinse or clean wounds.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ademetionine
Ademetionine is a substance that can help improve mood in depression and support liver function.
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Samyr

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Aminoplasmal E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliera di Padova
Azienda Ospedaliera di Padova - U.O.C. di Gastroenterologia
Padova, Italy
Dipartimento Salute Mentale c/o P.O.Maria SS. dello Splendore
DSM Giulianova c/o ospedale di Giulianova
Pesaro, Italy
Azienda Ospedaliero Universitaria Pisana
A.O. Universitaria Pisana - U.O. Psichiatria 2
Pisa, Italy

Sponsor: Mylan Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.