Major Depressive Disorder: Ketamine and ECT Study

We are investigating whether combining ketamine with electroconvulsive therapy helps people with treatment-resistant depression. The study also examines its effects on brain chemicals and cognitive function.

1-2 years ≤5 visits Confirmation phase (III)Standard Medicines InjectionPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ketamina Molteni

Ketamina Molteni is a medicine used to induce and maintain anesthesia and provide short-term pain relief during medical procedures.

Sodio Cloruro Baxter

Sodio Cloruro Baxter is a sterile salt solution used to replace body fluids, hydrate patients, and rinse wounds or medical devices.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ketamine

Ketamine is a fast-acting anesthetic substance used to induce anesthesia, relieve severe pain, and sometimes help with treatment-resistant depression.

Ketamine Hydrochloride

Ketamine hydrochloride is a substance that produces short-term anesthesia and pain relief for surgeries and severe pain.

Sodium Chloride

Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens

Addex Natriumklorid

Aminoplasmal E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Ospedale San Raffaele S.r.l.

Anesthesia and Intensive Care

Sesto San Giovanni, Italy

Sponsor: Universita' Vita-salute S. Raffaele

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.