Major Depressive Disorder: Minocycline vs. Celecoxib

We are studying whether minocycline or celecoxib can help patients with Major Depressive Disorder who haven't responded to previous treatments. The trial will compare how well these medications work and how patients respond to them.

≤3 months 6-10 visits Confirmation phase (III)Cost Reimbursement Standard Medicines OralPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Celecoxib

Celecoxib is a medicine used to reduce pain and swelling from arthritis and other short-term painful conditions.

Celecoxib Eg

Celecoxib Eg is a medicine used to reduce pain and inflammation, commonly for arthritis and other joint or muscle pain.

Minocycline Eg

Minocycline Eg is an antibiotic used to treat various bacterial infections, commonly prescribed for acne and other skin infections.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Celecoxib

Celecoxib is a substance that reduces pain and inflammation, commonly used to treat arthritis and other inflammatory conditions.

Minocycline

Minocycline is a substance that fights bacterial infections, commonly used for acne and skin or respiratory infections.

Minocycline Hydrochloride Dihydrate

Minocycline hydrochloride dihydrate is an antibiotic substance used to treat a range of bacterial infections, commonly including acne and skin infections.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aclexa

Algoxib

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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SINAPS

Duffel, Belgium

University Of Antwerp

CAPRI

Duffel, Belgium

UZ Brussel

Adult psychiatry

Ganshoren, Belgium

Sponsor: University Of Antwerp

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.