Major Depressive Disorder: New Treatment Approach

We are studying whether a six-week intensified medication treatment helps people with major depressive disorder who didn't respond to their first treatment. The goal is to see if this new approach improves symptoms and overall well-being compared to standard care.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Agomelatine Eg
Agomelatine Eg is a medicine used to treat depression.
Amitriptyline Bb
Amitriptyline Bb is a medicine used to treat depression and certain types of long-term nerve pain.
Atomoxetine
Atomoxetine is a medicine used to treat attention-deficit/hyperactivity disorder (ADHD) by helping improve focus and reduce impulsive behavior.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Agomelatine
Agomelatine is a substance used to treat depression by helping restore normal sleep-wake cycles and improve mood.
Amitriptyline
Amitriptyline is a substance that treats depression and is also used for certain chronic pain conditions and migraine prevention.
Amitriptyline Hydrochloride
Amitriptyline hydrochloride is a substance used to treat depression and some types of long-term nerve pain.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abrix
Acelopam
Aciprex

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Innsbruck
Universitätsklinik für Psychiatrie I (University Clinic for Psychiatry I)
Innsbruck, Austria
Universitätsklinik für Psychiatrie und Psychotherapie Bielefeld
Psychiatrie und Psychotherapy
Bielefeld, Germany
University Hospital Frankfurt am Main
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy
Frankfurt am Main, Germany

Sponsor: Universitair Medisch Centrum Utrecht
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.