Mantle-Cell Lymphoma: KTE-X19 CAR-T Cell Therapy

We are studying a new CAR-T cell therapy for patients with relapsed or refractory mantle-cell lymphoma who responded partially to ibrutinib. The trial aims to evaluate its effectiveness and safety in improving patient outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Imbruvica
Imbruvica is a medicine used to treat certain types of blood cancers, including some forms of lymphoma and leukemia.
Tecartus
Tecartus is a personalized cell therapy used to treat certain aggressive blood cancers in patients whose disease has returned or not responded to treatments.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Brexucabtagene Autoleucel
Brexucabtagene autoleucel uses a patient’s engineered immune cells to target and help eliminate certain B‑cell blood cancers such as lymphoma and leukemia.
Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Fludarabine Phosphate
Fludarabine phosphate is used to treat certain blood cancers, especially chronic lymphocytic leukemia and some lymphomas.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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IRCCS Azienda Ospedaliero-Universitaria Di Bologna
Dipartimento Malattie Oncologiche ed Ematologiche
Bologna, Italy
Fondazione IRCCS Istituto Nazionale Dei Tumori
SC Ematologia
Milan, Italy
Sponsor: Fondazione IRCCS Istituto Nazionale Dei Tumori
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.