Mantle Cell Lymphoma: Venetoclax with Ibrutinib and Rituximab

We are studying a new treatment combination for patients with Mantle Cell Lymphoma who cannot undergo high-dose therapy. The goal is to see how well it works compared to standard chemotherapy.

>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOralInjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bendamustine
Bendamustine is a chemotherapy medicine used to treat certain blood cancers, such as lymphoma and some types of leukemia.
Imbruvica
Imbruvica is a medicine used to treat certain types of blood cancers, including some forms of lymphoma and leukemia.
Venclyxto
Venclyxto is a medicine used to treat certain types of blood cancer, including some forms of leukemia and lymphoma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bendamustine
Bendamustine is a substance used to treat certain cancers, especially non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Bendamustine Hydrochloride
Bendamustine hydrochloride is a chemotherapy substance used to treat certain blood cancers by killing cancer cells.
Ibrutinib
Ibrutinib is a substance that targets immune cell signaling to treat certain blood cancers, such as chronic lymphocytic leukemia and mantle cell lymphoma.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Benda Nc
Bendamedac
Bendamustin Accord

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Staedtisches Klinikum Brandenburg GmbH
Innere Medizin - Klinik für Hämatologie und Onkologie
Brandenburg an der Havel, Germany
Klinikum Chemnitz gGmbH
Klinik für Innere Medizin III
Chemnitz, Germany
Kath. St. Paulus GmbH
Klinik für Innere Medizin II Onkozentrum
Dortmund, Germany
Sponsor: Universitatsmedizin der Johannes Gutenberg-Universitat Mainz KöR
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.