Aortic Valve Replacement Treatment
Aortic valve replacement is a surgical procedure to replace a damaged aortic valve with a mechanical one. Patients often require treatment with Vitamin K antagonists to prevent blood clots after the surgery.
Mechanical Heart Valves: Lower INR Study
We are evaluating if a lower INR range is safer and more effective for patients with bileaflet aortic mechanical valves. This may help reduce bleeding risks associated with current treatment methods.
>2 yearsConfirmation phase (III)No PlaceboPartially RemoteStandard MedicinesOralCardiologyInternal Medicine
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 18 years old?
- Have you had a bileaflet mechanical heart valve implant in the aortic position for at least 3 months?
- Are you pregnant or expecting to become pregnant during the study?
- Do you have a second implanted mechanical valve in any position?
- Is your INR (blood clotting test) lower than 2.0?
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
Acenocoumarol Aurobindo
Acenocumarol Aurovitas
Acenocumarol Generis
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Ziekenhuis Oost Limburg
Cardiology
Genk, Belgium
Imelda
Cardiac Surgery
Hever, Belgium
UZ Leuven
Cardiale Heelkunde
Heverlee, Belgium
Sponsor: Hamilton Health Sciences Corporation
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.