Medication-Related Osteonecrosis of the Jaw: PENTO Treatment Study

We are investigating whether the PENTO treatment can help heal jaw bone exposure in patients with MRONJ. The study will also look at pain levels, nutrition, and any side effects over time.

>2 years Efficacy phase (II)No Placebo Standard Medicines OralInternal MedicineOrthopedics and Traumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Clindamycin

Clindamycin is an antibiotic medicine used to treat various bacterial infections, including skin and respiratory infections.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Amoxicillin

Amoxicillin is an antibiotic substance used to treat a range of common bacterial infections such as ear, throat, and urinary tract infections.

Amoxicillin Sodium

Amoxicillin Sodium is an antibiotic substance used to treat common bacterial infections.

Clavulanic Acid

Clavulanic acid is a substance that helps certain antibiotics work against bacteria that would otherwise resist them.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aknet Duo

Aperox Gel

Cleocin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Et Universitaire De Limoges

Maxillofacial surgery

Isle, France

Sponsor: Centre Hospitalier Et Universitaire De Limoges

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.