Melanoma, NSCLC, and Cervical Cancer: ANV419 vs High-Dose IL-2

We are studying whether a new treatment (ANV419) is safer and improves outcomes compared to high-dose IL-2 for patients after tumor-infiltrating lymphocyte therapy. This trial also looks at quality of life and patient experiences.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Endoxan I.V
Endoxan I.V is a chemotherapy medicine given by IV infusion to treat several types of cancer and some serious autoimmune conditions.
Fludarabina Teva
Fludarabina Teva is a chemotherapy medicine used to treat certain blood cancers.
Fludarabinphosphat Ebewe
Fludarabinphosphat Ebewe is a chemotherapy medicine used to treat certain blood cancers, especially chronic lymphocytic leukemia.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Aldesleukin
Aldesleukin is a synthetic form of a natural immune-signaling protein that boosts the body's immune response to help treat certain cancers.
Cyclophosphamide Monohydrate
Cyclophosphamide monohydrate is an anti-cancer substance used to treat various cancers and some serious autoimmune diseases.
Fludarabine Phosphate
Fludarabine phosphate is used to treat certain blood cancers, especially chronic lymphocytic leukemia and some lymphomas.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

ANV419
Melanoma Tumor Infiltrating Lymphocytes
Autologous Tumor-Infiltrating Lymphocytes

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bendarabin
Bendarabin
Beneflur

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Herlev Hospital
Department of Oncology
Rødovre, Denmark
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Center for Cell Therapy
Amstelveen, Netherlands
Vall D Hebron Institute Of Oncology
Medical Oncology
Alboraya, Spain
Sponsor: Vall D Hebron Institute Of Oncology
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.