Melanoma Treatment: Pembrolizumab with New Agents

We are studying the safety and effectiveness of pembrolizumab alone or with new investigational treatments for people with melanoma. This research aims to find better options for managing this type of skin cancer.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.
Lenvima
Lenvima is a cancer medicine used to treat certain types of thyroid, liver, and kidney cancers.
Tretinoin Neon Healthcare
Tretinoin Neon Healthcare is a topical medicine used to treat acne and improve skin texture and appearance.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Lenvatinib
Lenvatinib is a substance that helps treat certain types of cancer by blocking signals tumors use to grow and spread.
Pembrolizumab
Pembrolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-1.
Tretinoin
Tretinoin is a topical substance that helps clear acne and improve skin texture and signs of aging by speeding skin cell renewal.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Favezelimab
MK-1308A
MK-4280A

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Airol
Atralin
Avitcid

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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CHU De Bordeauxt
Service de Dermatologie
Bordeaux, France
Assistance Publique Hopitaux De Marseille
Service de Dermatologie
Marseille, France
Centre Hospitalier Lyon Sud
Service de Dermatologie
Oullins, France

Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.