Melanoma with Brain Metastases: Immunotherapy Study

We are studying the effects of immunotherapy in melanoma patients with brain metastases who are also receiving steroid treatment. Our goal is to see if this combination improves outcomes compared to standard care.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.
Opdivo
Opdivo is a cancer medicine that helps the immune system find and fight tumor cells.
Yervoy
Yervoy is a cancer medicine that helps the immune system find and attack melanoma and some other types of tumors.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Binimetinib
Binimetinib is a targeted cancer treatment that blocks a protein pathway to slow growth of certain tumors, including some melanomas.
Dabrafenib
Dabrafenib is a substance that targets a specific gene mutation to treat certain cancers, especially melanoma.
Encorafenib
Encorafenib is a substance that targets cancer cells with a specific BRAF gene mutation to help slow tumor growth.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Opdualag

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Aarhus Universitet
Department of Oncology
Århus, Denmark
Odense University Hospital
Department of Oncology
Odense, Denmark
Region Hovedstaden
Department of Oncology
Rødovre, Denmark
Sponsor: Region Hovedstaden
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.