MEPENDAX: Axitinib and Etoposide for Pediatric Brain Tumors

We are studying a new treatment combining axitinib and oral etoposide for children and young adults with relapsing medulloblastoma or ependymoma. The goal is to find the safest dose and see if it helps improve survival.

>2 years≤5 visitsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOralInjectionNeurologyOncologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Etoposide Viatris
Etoposide Viatris is a chemotherapy medicine used to treat various types of cancer.
Inlyta
Inlyta is a cancer medicine used to treat advanced kidney cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Axitinib
Axitinib is a substance that helps slow the growth of certain cancers, mainly advanced kidney cancer.
Etoposide
Etoposide is a substance used to treat certain cancers by stopping fast-growing cancer cells from dividing.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Celltop

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aksitinib Alpha-Medical
Aksitinib Sandoz
Aksitinib Teva

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire D'Angers
Immuno-Hémato-Oncologie pédiatrique
Angers, France
Centre Hospitalier Universitaire De Bordeaux
Onco-Hématologie Pédiatrique
Bordeaux, France
Les Hopitaux Universitaires De Strasbourg
Oncologie-Hématologie Pédiatrique
Eckbolsheim, France
Sponsor: Assistance Publique Hopitaux De Marseille
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.