Metastatic Colorectal Cancer: Atezolizumab with FOLFOXIRI

We are studying whether adding Atezolizumab to standard treatment helps patients with unresectable metastatic colorectal cancer live longer without disease progression. The trial also looks at the safety and quality of life for participants.

3-6 months Confirmation phase (III)No Placebo Standard Medicines InjectionGastroenterologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Irinotecan

Irinotecan is a chemotherapy medicine used to treat certain cancers, especially colorectal cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Atezolizumab

Atezolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-L1.

Bevacizumab

Bevacizumab is a substance that blocks formation of new blood vessels to treat certain cancers and eye conditions caused by abnormal vessel growth.

Calcium Folinate

Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Campto

Canri

Chlorhydrate D'irinotécan Trihydraté Sun

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centro Di Riferimento Oncologico Di Aviano

Medical Oncology and Oncological Prevention

Aviano-Castello, Italy

Fondazione Poliambulanza

Medical Oncology

Brescia, Italy

Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco Di Catania

Medical Oncology

Canalicchio, Italy

Sponsor: Gruppo Oncologico Del Nord Ovest

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.