Metastatic Colorectal Cancer: Trifluridine/Tipiracil with Panitumumab vs. Bevacizumab

We are studying two treatment combinations to find out which one works better for people with metastatic colorectal cancer. The trial also looks at safety and how treatments affect patients' quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Lonsurf
Lonsurf is a cancer medicine used to treat advanced colorectal and stomach cancers when other treatments have failed.
Vectibix
Vectibix is a cancer medicine used to treat certain types of advanced colorectal (colon) cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bevacizumab
Bevacizumab is a substance that blocks formation of new blood vessels to treat certain cancers and eye conditions caused by abnormal vessel growth.
Panitumumab
Panitumumab is a laboratory-made antibody used to treat certain advanced colorectal cancers by blocking a protein that helps tumor cells grow.
Tipiracil
Tipiracil is a substance used alongside an anti-cancer agent to help treat advanced colorectal and stomach cancers by boosting the agent's effectiveness.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Virophta

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Klinikum St Marien Amberg
Studienzentrum
Amberg, Germany
Sozialstiftung Bamberg Klinik am Bruderwald
Studienzentrale
Bamberg, Germany
Klinikum Bayreuth GmbH
Med. Klinik IV - Innere Medizin
Bayreuth, Germany

Sponsor: Charite Universitaetsmedizin Berlin KöR
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.