Metastatic Colorectal Cancer: Valproic Acid and Standard Treatment

We are studying a new combination of Valproic acid with standard therapies for patients with metastatic colorectal cancer who have already been treated. The goal is to see if this combination improves survival and quality of life compared to standard treatment alone.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Irinotecan Accord
Irinotecan Accord is a chemotherapy medicine used to treat certain cancers, commonly colorectal cancer.
Vectibix
Vectibix is a cancer medicine used to treat certain types of advanced colorectal (colon) cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Irinotecan
Irinotecan is a chemotherapy substance used to treat certain cancers by blocking cancer cells from dividing and growing.
Irinotecan Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate is a chemotherapy agent used to treat several types of cancer, especially colorectal cancer.
Panitumumab
Panitumumab is a laboratory-made antibody used to treat certain advanced colorectal cancers by blocking a protein that helps tumor cells grow.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Campto
Canri
Chlorhydrate D'irinotécan Trihydraté Sun

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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AORN San Giuseppe Moscati Avellino
Medical Oncology
Avellino, Italy
Azienda Ospedaliera Sant'anna E San Sebastiano Di Caserta
Medical Oncology Unit
Caserta, Italy
Ospedale Civile San Giovanni di Dio - Frattamaggiore
Oncology
Frattamaggiore, Italy

Sponsor: IRCCS Istituto Nazionale Tumori Fondazione Pascale
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.