Metastatic Leiomyosarcoma: Lurbinectedin and Doxorubicin Study

We are investigating whether combining lurbinectedin with doxorubicin helps patients with metastatic leiomyosarcoma live longer without disease progression compared to doxorubicin alone. This study aims to improve treatment options for this rare cancer.

>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Filgrastim Hexal
Filgrastim Hexal is a medicine that boosts white blood cell production to help reduce infection risk during chemotherapy or after bone marrow transplant.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dexamethasone Sodium Phosphate
Dexamethasone sodium phosphate is a corticosteroid substance that reduces inflammation and suppresses the immune response.
Doxorubicin Hydrochloride
Doxorubicin hydrochloride is a chemotherapy substance used to treat various cancers by killing or slowing the growth of cancer cells.
Filgrastim
Filgrastim is a substance that stimulates production of neutrophils, a type of white blood cell, to help prevent infections in people with low counts.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Accofil
Granulokine
Grastofil

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz
Department of Internal Medicine, Division of Oncology
Graz, Austria
Medizinische Universitaet Innsbruck
Department of Hematology and Oncology
Innsbruck, Austria
Ordensklinikum Linz GmbH
Interne I: Medical Oncology and Hematology
Linz, Austria
Sponsor: Pharma Mar S.A.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.