Metastatic Melanoma: Diclofenac with PD-1 Inhibitor

We are studying whether adding diclofenac to ongoing PD-1 inhibitor therapy helps patients with metastatic melanoma who have stable disease. This trial aims to evaluate the potential benefits of this combination treatment.

>2 years Efficacy phase (II)Confirmation phase (III)No Placebo Standard Medicines Oral InjectionDermatologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Diclo 50 - 1 A Pharma

Diclo 50 is a pain-relief medicine used to reduce inflammation and relieve pain from arthritis, injuries, or menstrual cramps.

Diclofenac-Natrium Al

Pantoprazol Tad

Pantoprazol Tad is a medicine that reduces stomach acid to relieve heartburn, acid reflux, and help heal stomach ulcers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Diclofenac Sodium

Diclofenac sodium is a substance that reduces pain and inflammation from arthritis and other muscle or joint problems.

Diclofenac Sodium Ph. Eur.

Diclofenac sodium is a substance that reduces pain and inflammation in conditions like arthritis, injuries, and menstrual cramps.

Nivolumab

Nivolumab is a substance that helps the immune system recognize and attack certain cancers.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aceclofen

Acidwell

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitaetsklinikum Essen AöR

Abteilung für Dermatologie

Essen, Germany

Universitaetsmedizin Der Johannes Gutenberg-Universitaet Mainz

Abteilung für Dermatologie

Mainz, Germany

Universitaetsklinikum Regensburg

Abteilung für Dermatologie

Pentling, Germany

Sponsor: Universitaetsklinikum Regensburg

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.