Metastatic Pancreatic Cancer: 5-FU with NALIRI or NALIRINOX

We are studying two new treatment combinations for patients with metastatic pancreatic ductal adenocarcinoma who have progressed after prior therapies. The aim is to see if these combinations improve survival and are safe to use.

Efficacy phase (II)No Placebo Standard Medicines InjectionGastroenterologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Elvorine

Fluorouracil Accord Healthcare

Fluorouracil Accord Healthcare is a chemotherapy medicine used to treat several types of cancer by slowing or stopping cancer cell growth.

Levofolic

Levofolic is a folate supplement used to prevent or treat folate deficiency and support healthy pregnancy.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Levofolinate

Calcium levofolinate is a substance that helps protect healthy cells during some cancer treatments and restores folate levels.

Fluorouracil

Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.

Irinotecan

Irinotecan is a chemotherapy substance used to treat certain cancers by blocking cancer cells from dividing and growing.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

5-Fluorouracil

5-Fluorouracil Ebewe

5-Fluorouracil Sandoz

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Az Sint-Lucas

Gastro-oncology

Assebroek, Belgium

Grand Hopital De Charleroi

Oncologie-hematologie

Charleroi, Belgium

CHU Helora

Gastro-oncology

Fayt-lez-Manage, Belgium

Sponsor: Groupe Belge D'Oncologie Digestive

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.