Metastatic Renal Cell Carcinoma: Temferon Gene Therapy

We are testing a new gene therapy using modified stem cells for patients with metastatic renal cell carcinoma. The study aims to evaluate the safety and biological response to a single dose of Temferon.

1-2 years 16-20 visits Safety phase (I)Efficacy phase (II)No Placebo Investigational Medicines Oral InjectionHematologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cabozantinib Ipsen

Cabozantinib Ipsen is a cancer medicine used to treat certain advanced kidney, liver, and thyroid cancers.

Filgrastim Hexal

Filgrastim Hexal is a medicine that boosts white blood cell production to help reduce infection risk during chemotherapy or after bone marrow transplant.

Plerixafor

Plerixafor helps move blood-forming stem cells into the bloodstream so they can be collected for transplant in certain blood cancers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Busulfan

Busulfan is a substance used to destroy bone marrow cells before a bone marrow transplant and to treat certain blood cancers.

Cabozantinib

Cabozantinib is a substance used to treat certain advanced cancers by blocking signals that help tumors grow and spread.

Filgrastim

Filgrastim is a substance that stimulates production of neutrophils, a type of white blood cell, to help prevent infections in people with low counts.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Temferon

Autologous CD34+ Haematopoietic Stem and Progenitor Cells Transduced with a Lentiviral Vector Encoding the Interferon Alpha-2 Gene

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Accofil

Cabometyx

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Ospedale San Raffaele S.r.l.

Oncologia Medica

Vimodrone, Italy

Sponsor: Genenta Science S.p.A.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.