Metastatic Renal Cell Carcinoma: Treatment Comparison Study

We are comparing two treatment combinations for patients with metastatic renal cell carcinoma to see which one improves survival and quality of life. This study is for those who have not received treatment before and have specific risk factors.

11-15 visits Confirmation phase (III)No Placebo Standard Medicines Oral InjectionInternal MedicineOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Axitinib Sandoz

Axitinib Sandoz is a cancer medicine used to treat advanced kidney cancer.

Cabometyx

Cabometyx is a cancer medicine used to treat certain advanced kidney and liver cancers.

Keytruda

Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Axitinib

Axitinib is a substance that helps slow the growth of certain cancers, mainly advanced kidney cancer.

Cabozantinib

Cabozantinib is a substance used to treat certain advanced cancers by blocking signals that help tumors grow and spread.

Ipilimumab

Ipilimumab is a substance that helps the immune system attack cancer by blocking a protein that keeps immune cells from working.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aksitinib Alpha-Medical

Aksitinib Sandoz

Aksitinib Teva

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Vienna

Department of Urology

Vienna, Austria

Medical University Of Vienna

Deputy PI Department of Urology

Vienna, Austria

Masarykuv Onkologicky Ustav

ONCOLOGIE

Brno, Czechia

Sponsor: Institut Gustave Roussy

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.