Metastatic Uveal Melanoma: IDE196 and Crizotinib Combination

We are studying a new combination treatment for HLA-A2 negative metastatic uveal melanoma to see if it works better than current options. The trial will also evaluate the safety and quality of life for participants.

>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboCost ReimbursementPartially RemoteInvestigational MedicinesOralInjectionOncologyOphthalmology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dacarbazine
Dacarbazine is a chemotherapy medicine used to treat certain cancers, such as melanoma and Hodgkin lymphoma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Crizotinib
Crizotinib is a substance that blocks specific cancer cell signals to treat certain types of lung cancer with particular genetic changes.
Dacarbazine
Dacarbazine is a chemotherapy substance used to treat certain cancers, including melanoma and Hodgkin lymphoma.
Dacarbazine Citrate
Dacarbazine citrate is an anticancer substance used to treat certain cancers, including melanoma and Hodgkin lymphoma.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ide196
Darovasertib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Dacarbazin Lipomed
Dacarbazina Lipomed
Dacarbazina Medac

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven
General Medical Oncology
Heverlee, Belgium
Cliniques Universitaires Saint-Luc
Medical Oncology
Sint-Stevens-Woluwe, Belgium
Centre Léon Bérard
Medical Oncology
La Mulatière, France
Sponsor: Ideaya Biosciences Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.