MK-2870 vs Chemotherapy for Advanced Lung Cancer

We are studying a new treatment, MK-2870, for patients with advanced nonsquamous non-small cell lung cancer who have specific genetic mutations. The goal is to see if it works better than standard chemotherapy options.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Paracetamol
Paracetamol relieves pain and reduces fever for conditions like headaches, muscle aches, and colds.
Pemetrexed
Pemetrexed is a chemotherapy medicine used to treat certain types of lung cancer and mesothelioma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Acetylsalicylic Acid
Acetylsalicylic acid is a substance that reduces pain, fever, and inflammation and can help prevent blood clots.
Anhydrous Docetaxel
Anhydrous Docetaxel is a substance used to treat various cancers by stopping cancer cells from dividing.
Betamethasone Sodium Phosphate Ph. Eur
Betamethasone sodium phosphate is a substance that reduces inflammation and calms the immune system.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mk-2870

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

4-In-One Flu Relief
6 Years Plus Paracetamol Boots
Abacat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Masarykuv Onkologicky Ustav
Klinika komplexni onkologicke pece
Brno, Czechia
University Hospital Olomouc
Klinika plicnich nemoci a tuberkulozy
Olomouc, Czechia
Nemocnice AGEL Ostrava-Vitkovice a.s.
Plicni oddeleni
Ostrava, Czechia

Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.