MK-5684 Therapies for Advanced Prostate Cancer

We are studying the safety and effectiveness of MK-5684-based treatments for men with metastatic castration-resistant prostate cancer. This research aims to find better options for managing this advanced stage of cancer.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cabazitaxel
Cabazitaxel is a chemotherapy medicine used to treat advanced prostate cancer after other treatments have stopped working.
Hydrocortisone
Hydrocortisone is a steroid medicine used to reduce inflammation and treat skin rashes, eczema, allergic reactions, and some hormone problems.
Olapine
Olapine is a medicine used to treat schizophrenia and bipolar disorder, helping control symptoms like hallucinations, delusions, and extreme mood changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cabazitaxel
Cabazitaxel is a chemotherapy substance used to treat advanced prostate cancer by killing rapidly dividing cells.
Cabazitaxel 2-Propanol Solvate
Cabazitaxel is a chemotherapy substance used to treat advanced prostate cancer that no longer responds to other treatments.
Dexamethasone
Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abix
Acecort
Actocortina

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Aalborg University Hospital
Department of Oncology
Aalborg, Denmark
Herlev Hospital
Department of Oncology
Rødovre, Denmark
Docrates Oy
Docrates Cancer Center
Helsinki, Finland

Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.