Moderate Acne: Oral Isotretinoin vs. Standard Care

We are comparing a new oral medication to standard treatments for moderate acne in patients with skin of color. Our goal is to see if this new approach improves acne severity and quality of life.

6-12 months 6-10 visits Confirmation phase (III)No Placebo Standard Medicines OralDermatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Adapalene Zentiva

Adapalene Zentiva is a topical medicine used to treat acne by helping clear and prevent pimples.

Differin

Differin is a topical medicine used to treat and prevent acne by clearing pimples and blackheads.

Doxycycline Eg

Doxycycline Eg is an antibiotic medicine used to treat many bacterial infections, such as lung, skin, and bladder infections.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Adapalene

Adapalene is a topical substance used to treat acne by reducing pimples and preventing clogged pores.

Doxycycline

Doxycycline is an antibiotic substance used to treat a wide range of bacterial infections, including respiratory, skin, and tick-borne illnesses.

Isotretinoin

Isotretinoin is a retinoid substance used to treat severe cystic acne by reducing oil production and skin inflammation.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

A-Cnotren

Acmotren

Acnelec

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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CHU De Martinique

Dermatologie

Amilly, France

Centre Hospitalier Victor Dupouy Argenteuil

Dermatologie

Argenteuil, France

Centre Hospitalier Universitaire De Bordeaux

Dermatologie

Bordeaux, France

Sponsor: Centre Hospitalier Universitaire De Nice

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.