Multiple Myeloma: Selinexor with Dexamethasone and Bortezomib

We are studying different combinations of Selinexor, Dexamethasone, and Bortezomib for patients with hard-to-treat multiple myeloma. Our goal is to see how well these treatments work and how safe they are.

3-6 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesOralInjectionHematologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bortezomib Accord
Bortezomib Accord is a cancer medicine used to treat multiple myeloma and certain types of lymphoma.
Ondansetron Aurobindo
Ondansetron Aurobindo is a medicine used to prevent nausea and vomiting from chemotherapy, radiation, or after surgery.
Zyprexa
Zyprexa is a medicine used to treat schizophrenia and bipolar disorder, reducing severe mood swings and symptoms like hearing voices.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bortezomib
Bortezomib is a substance that blocks cellular protein breakdown to treat certain blood cancers, including multiple myeloma.
Dexamethasone
Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.
Olanzapine
Olanzapine is a substance used to treat schizophrenia and bipolar disorder by helping reduce psychotic symptoms and stabilize mood.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Dexamethasone

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abormib
Adabonib
Aedon

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Alexandra Hospital
Plasma Cell Dyscrasias Unit Department of Clinical Therapeutics
Athens, Greece
Evangelismos S.A.
Hematology and Lymphoma Department
Athens, Greece
Theageneio Cancer Hospital
Hematology
Thessaloníki, Greece
Sponsor: Karyopharm Therapeutics Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.