Multiple Sclerosis: Frexalimab vs. Teriflunomide

We are studying a new medication, frexalimab, for adults with relapsing forms of multiple sclerosis. The goal is to see if it works better than teriflunomide in reducing relapses and improving quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Colestyramin Ratiopharm
Colestyramin Ratiopharm is a medicine used to lower high cholesterol by trapping cholesterol-related substances in the gut.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Colestyramine
Colestyramine is a substance that lowers high cholesterol by binding bile acids in the intestines.
Gadobutrol
Gadobutrol is a contrast agent used in MRI scans to improve the visibility of blood vessels and body tissues.
Teriflunomide
Teriflunomide is a substance that reduces immune system activity to help prevent relapses in people with relapsing multiple sclerosis.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Frexalimab

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cholestyramine
Colestyramin 1 A Pharma
Colestyramin Orifarm

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medizinische Universitaet Innsbruck
University Hospital for Neurology
Innsbruck, Austria
Universitair Ziekenhuis Gent
Neurology
Ledeberg, Belgium
Noorderhart
Revalidatie en MS centrum
Overpelt, Belgium

Sponsor: Sanofi-Aventis Research & Development
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.