Myelodysplastic Syndrome (MDS)
Myelodysplastic Syndrome (MDS) is a group of blood disorders characterized by ineffective blood cell production, leading to symptoms such as fatigue, weakness, and an increased risk of infections and bleeding.
Myelodysplastic Syndromes: Ivosidenib vs. Azacitidine
We are studying the effects of a new drug, ivosidenib, in adults with myelodysplastic syndromes who have an IDH1 mutation. The goal is to understand its effectiveness and safety compared to azacitidine.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Hypomethylating Agent Naive Myelodysplastic Syndromes
Hypomethylating Agent Naive Myelodysplastic Syndromes refer to a subtype of MDS where patients have not previously received treatment with hypomethylating agents, leading to similar symptoms as MDS.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 18 and 75 years old?
- Do you have a diagnosis of MDS (myelodysplastic syndrome) with specific mutations?
- Have you had any prior treatment for MDS, such as chemotherapy or stem cell transplant?
- Do you have low blood counts, like less than 100 platelets, less than 1000 neutrophils, or hemoglobin less than 10g/dL?
- Is your blast count (immature blood cells) between 5% and 19%?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Ag-120/S95031
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
Azacitdine Clonmel
Azacitidin
Azacitidin Aliud
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Centre Hospitalier Universitaire De Bordeaux
Service d'hématologie clinique et thérapie cellulaire
Canéjan, France
CHRU De Nancy
Service d'hématologie clinique
Carros, France
Centre Hospitalier Universitaire De Nantes
Service hématologie clinique
Nantes, France
Sponsor: Institut De Recherches Internationales Servier IRIS
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.