Myelofibrosis: Navtemadlin with Ruxolitinib

We are studying whether adding navtemadlin to ruxolitinib helps patients with myelofibrosis who aren't responding well to their current treatment. The trial looks at changes in spleen size and symptoms, along with safety and survival.

>2 years Confirmation phase (III)Post-Trial Drug Access Cost Reimbursement Investigational Medicines OralHematologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Loperamid Wzf

Loperamid Wzf is a medicine used to stop or reduce diarrhea and ease frequent bowel movements.

Navalem

Ondansetron

Ondansetron is a medicine that helps prevent nausea and vomiting after surgery or during cancer treatment.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Doxylamine Hydrogen Succinate

Doxylamine hydrogen succinate is a sedating antihistamine used to relieve allergy symptoms and help with short-term insomnia.

Loperamide

Loperamide is a substance that slows intestinal movement to reduce and control diarrhea.

Loperamide Hydrochloride

Loperamide hydrochloride is a substance that slows the intestines to reduce diarrhea and control urgent or loose bowel movements.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Navtemadlin

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acute Diarrhoea Relief

Aero-Om Antidiarreico

Aero-Om Antidiarreico Rapid

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz

Department of Internal Medicine Clinical Department of Hematology

Graz, Austria

Medizinische Universitaet Innsbruck

Medical University Innsbruck, Department of Internal Medicine V (Hematology and Oncology)

Innsbruck, Austria

Steiermaerkische Krankenanstalten Ges.m.b.H.

LKH Hochsteiermark, Department of Internal Medicine, Hematology and Internal Oncology

Leoben, Austria

Sponsor: Kartos Therapeutics Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.