Myelofibrosis: Selinexor Treatment Study

We are studying the effects of selinexor in patients with myelofibrosis who haven't been treated with JAK inhibitors. The goal is to see if it helps improve symptoms and overall health.

6-10 visits Efficacy phase (II)No Placebo Cost Reimbursement Investigational Medicines OralHematology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Aprepitant Aprepitant

Aprepitant is a medicine used to prevent nausea and vomiting caused by chemotherapy or surgery.

Jakavi

Jakavi is a medicine used to treat certain serious blood disorders that affect bone marrow and blood cell production.

Ondansetron

Ondansetron is a medicine that helps prevent nausea and vomiting after surgery or during cancer treatment.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Aprepitant

Aprepitant is a substance that prevents nausea and vomiting by blocking a brain receptor, often used with chemotherapy or after surgery.

Netupitant

Netupitant is a substance that helps prevent nausea and vomiting caused by chemotherapy.

Ondansetron

Ondansetron is a substance that prevents nausea and vomiting, especially related to chemotherapy, radiation therapy, or after surgery.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Pacritinib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Akynzeo

Aloxi

Aprepilor

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven

Hematology

Heverlee, Belgium

Universitair Ziekenhuis Gent

Hematology

Ledeberg, Belgium

Umbal - Prof. D-R Stoyan Kirkovich AD

Department of Clinical Hematology

Kardzhali, Bulgaria

Sponsor: Karyopharm Therapeutics Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.